Drug repurposing approach to fight COVID-19

TU Singh, S Parida, MC Lingaraju, M Kesavan… - Pharmacological …, 2020 - Springer
Currently, there are no treatment options available for the deadly contagious disease,
coronavirus disease 2019 (COVID-19). Drug repurposing is a process of identifying new …

COVID-19 in immunocompromised hosts: what we know so far

M Fung, JM Babik - Clinical Infectious Diseases, 2021 - academic.oup.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused significant morbidity and …

Emerging treatment strategies for COVID-19 infection

M Gavriatopoulou, I Ntanasis-Stathopoulos… - Clinical and …, 2021 - Springer
The new type of coronavirus (COVID-19), SARS-CoV-2 originated from Wuhan, China and
has led to a worldwide pandemic. COVID-19 is a novel emerging infectious disease caused …

Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort

P Vizcarra, MJ Pérez-Elías, C Quereda, A Moreno… - The lancet HIV, 2020 - thelancet.com
Background Information about incidence, clinical characteristics, and outcomes of HIV-
infected individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Potent noncovalent inhibitors of the main protease of SARS-CoV-2 from molecular sculpting of the drug perampanel guided by free energy perturbation calculations

CH Zhang, EA Stone, M Deshmukh… - ACS central …, 2021 - ACS Publications
Starting from our previous finding of 14 known drugs as inhibitors of the main protease
(Mpro) of SARS-CoV-2, the virus responsible for COVID-19, we have redesigned the weak …

Hydroxychloroquine for early treatment of adults with mild coronavirus disease 2019: a randomized, controlled trial

O Mitjà, M Corbacho-Monné, M Ubals… - Clinical Infectious …, 2021 - academic.oup.com
Background No effective treatments for coronavirus disease 2019 (COVID-19) exist. We
aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be …

SARS-CoV-2 antiviral therapy

K Tao, PL Tzou, J Nouhin, H Bonilla… - Clinical microbiology …, 2021 - Am Soc Microbiol
The development of effective antiviral therapy for COVID-19 is critical for those awaiting
vaccination, as well as for those who do not respond robustly to vaccination. This review …

Immune deficiency is a risk factor for severe COVID‐19 in people living with HIV

C Hoffmann, JL Casado, G Härter, P Vizcarra… - HIV …, 2021 - Wiley Online Library
Objectives A prior T cell depletion induced by HIV infection may carry deleterious
consequences in the current COVID‐19 pandemic. Clinical data on patients co‐infected with …

Pathogenesis of multiple organ injury in COVID-19 and potential therapeutic strategies

M Lopes-Pacheco, PL Silva, FF Cruz… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory disease coronavirus 2 (SARS-CoV-2, formerly 2019-nCoV) is a
novel coronavirus that has rapidly disseminated worldwide, causing the coronavirus disease …

A review of potential suggested drugs for coronavirus disease (COVID-19) treatment

P Tarighi, S Eftekhari, M Chizari, M Sabernavaei… - European Journal of …, 2021 - Elsevier
The latest pandemic, coronavirus disease-2019 (COVID-19), is associated with high
prevalence and easy transmission, which is expanding globally with no conventional …