Remote ischemic conditioning

G Heusch, HE Bøtker, K Przyklenk, A Redington… - Journal of the American …, 2015 - jacc.org
In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with
reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and …

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

DJ Hausenloy, JA Barrabes, HE Bøtker… - Basic research in …, 2016 - Springer
To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers
in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the …

New horizons for newborn brain protection: enhancing endogenous neuroprotection

KJ Hassell, M Ezzati, D Alonso-Alconada… - Archives of Disease in …, 2015 - fn.bmj.com
Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …

The coronary circulation as a target of cardioprotection

G Heusch - Circulation research, 2016 - Am Heart Assoc
The atherosclerotic coronary vasculature is not only the culprit but also a victim of
myocardial ischemia/reperfusion injury. Manifestations of such injury are increased vascular …

Cardioprotection by remote ischemic conditioning and its signal transduction

P Kleinbongard, A Skyschally, G Heusch - Pflügers Archiv-European …, 2017 - Springer
Cardioprotective strategies aim to salvage myocardium from ischemia/reperfusion injury and
to reduce infarct size and its consequences. Different stimuli, acting at sites remote from the …

Rational modulation of the innate immune system for neuroprotection in ischemic stroke

D Amantea, G Micieli, C Tassorelli… - Frontiers in …, 2015 - frontiersin.org
The innate immune system plays a dualistic role in the evolution of ischemic brain damage
and has also been implicated in ischemic tolerance produced by different conditioning …

Translation of remote ischaemic preconditioning into clinical practice

RK Kharbanda, TT Nielsen, AN Redington - The Lancet, 2009 - thelancet.com
Reduction of the burden of ischaemia-reperfusion injury is the aim of most treatments for
cardiovascular and cerebrovascular disease. Although many strategies have proven benefit …

Repeated remote ischemic postconditioning protects against adverse left ventricular remodeling and improves survival in a rat model of myocardial infarction

M Wei, P Xin, S Li, J Tao, Y Li, J Li, M Liu, J Li… - Circulation …, 2011 - Am Heart Assoc
Rationale: Remote ischemic conditioning induced by repeated episodes of transient limb
ischemia is a clinically applicable method for protecting the heart against injury at the time of …

Remote ischemic conditioning: from bench to bedside

SY Lim, DJ Hausenloy - Frontiers in physiology, 2012 - frontiersin.org
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue
against the detrimental effects of acute ischemia-reperfusion injury (IRI). It describes an …

Seven-day remote ischemic preconditioning improves local and systemic endothelial function and microcirculation in healthy humans

H Jones, N Hopkins, TG Bailey… - American journal of …, 2014 - academic.oup.com
BACKGROUND Ischemic preconditioning (IPC) protects tissue against ischemia-induced
injury inside and outside ischemic areas. The purpose was to examine the hypothesis that …