Alzheimer's disease: treatment strategies and their limitations

E Passeri, K Elkhoury, M Morsink, K Broersen… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is the most frequent case of neurodegenerative disease and is
becoming a major public health problem all over the world. Many therapeutic strategies …

Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders

F Fanizza, M Campanile, G Forloni… - Journal of Tissue …, 2022 - journals.sagepub.com
The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs
development pipeline by mimicking the physiological environment and functions of human …

Harnessing cerebral organoids for Alzheimer's disease research

A Bubnys, LH Tsai - Current opinion in neurobiology, 2022 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting the aging
population. Despite many studies, there remains an urgent need to identify the root causes …

Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype

TG Mathes, M Monirizad, M Ermis, NR de Barros… - Acta Biomaterialia, 2024 - Elsevier
Self-assembling peptide-based hydrogels have become a highly attractive scaffold for three-
dimensional (3D) in vitro disease modeling as they provide a way to create tunable matrices …

Modeling the neuroimmune system in Alzheimer's and Parkinson's diseases

W Balestri, R Sharma, VA da Silva, BC Bobotis… - Journal of …, 2024 - Springer
Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders
caused by the interaction of genetic, environmental, and familial factors. These diseases …

Current progress of cerebral organoids for modeling Alzheimer's disease origins and mechanisms

S Sreenivasamurthy, M Laul, N Zhao… - Bioengineering & …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a progressive, neurodegenerative disease that has emerged as
a leading risk factor for dementia associated with increasing age. Two‐dimensional (2D) cell …

Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic …

G Garcia, S Pinto, M Cunha, A Fernandes, J Koistinaho… - Cells, 2021 - mdpi.com
Neuronal miRNA dysregulation may have a role in the pathophysiology of Alzheimer's
disease (AD). miRNA (miR)-124 is largely abundant and a critical player in many neuronal …

Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease

MA Hernández-Sapiéns… - Neural Regeneration …, 2022 - journals.lww.com
The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset
familial Alzheimer's disease, harboring~ 300 causative mutations, and representing~ 90% of …

Engrafted stem cell therapy for Alzheimer's disease: A promising treatment strategy with clinical outcome

L Kumar - Journal of Controlled Release, 2021 - Elsevier
To date, although the microscopic alterations present in Alzheimer's disease (AD) have
been well known for over a century only a handful of symptomatic treatments have been …

BACE1 inhibitors: A promising therapeutic approach for the management of Alzheimer's disease

R Arya, S Jain, S Paliwal, K Madan… - Asian Pacific Journal …, 2024 - journals.lww.com
Alzheimer's disease is a neurological disorder marked by the accumulation of amyloid beta
(Aβ) aggregates, resulting from mutations in the amyloid precursor protein. The enzyme β …