HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

This systematic review summarizes pharmacogenetic studies on antidepressant response
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …

We are beginning to appreciate the increasing complexity of mammalian gene structure. A
phenomenon that adds an important dimension to this complexity is the use of alternative …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Gene regulatory changes are thought to be major factors driving species evolution, with
creation of new regulatory regions likely being instrumental in contributing to diversity …

The 5-hydroxytryptamine type-3 (5-HT3) receptor is a cation-selective ion channel of the Cys-
loop superfamily. 5-HT3 receptor activation in the central and peripheral nervous systems …

The 5-HT3 receptor is a neurotransmitter-gated ion channel. It is a member of the Cys-loop
family of receptors, which also includes nicotinic acetylcholine, glycine and GABAA …

Serotonin type 3 (5-HT3) receptors are pentameric ion channels belonging to the
superfamily of Cys-loop receptors. Receptor activation either leads to fast excitatory …

Personalized medicine—the adaptation of therapies based on an individual's genetic and
molecular profile—is one of the most promising aspects of modern medicine. The …