Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

A growing number of epidemiological and experimental studies has established that
circadian disruption is strongly associated with psychiatric disorders, including major …

JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates
microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral …

Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine
kinases, were first described for their role in sodium sensing but have since been shown to …

Twenty-four-hour rhythms in immune parameters and functions are robustly observed
phenomena in biomedicine. Here, we summarize the important role of sleep and associated …

Chronic short sleep or extended wake periods are commonly observed in most
industrialized countries. Previously neurobehavioral impairment following sleep loss was …

We propose a statistical framework ISLET to infer individual-specific and cell-type-specific
transcriptome reference panels. ISLET models the repeatedly measured bulk gene …

Sleep deprivation, alone or in combination with pharmacological treatment and as part of a
chronotherapy package, is of potential use for people with major depressive episodes …

Background Sleep deprivation (SD) has been suggested to have a rapid antidepressant
effect. There is substantial evidence that neuroinflammation and neuroplasticity play critical …

Background Circadian rhythm was involved in the pathogenesis of depression. The
detection of circadian genes and white matter (WM) integrity achieved increasing focus for …