Cartilage equivalents from hydrogels containing chondrocytes exhibit excellent potential in
hyaline cartilage regeneration, yet current approaches have limited success at reconstituting …

The self-organization of embryonic stem cells (ESCs) into organized tissues with three
distinct germ layers is critical to morphogenesis and early development. While the regulation …

Cellular phenotypes and functional responses are modulated by the signals present in their
microenvironment, including extracellular matrix (ECM) proteins, tissue mechanical …

Biomechanics in embryogenesis is a dynamic field intertwining the physical forces and
biological processes that shape the first days of a mammalian embryo. From the first cell fate …

The development and application of micropatterning technology play a promising role in the
manipulation of biological substances and the exploration of life sciences at the microscale …

Lumenogenesis within the epiblast represents a critical step in early human development,
priming the embryo for future specification and patterning events. However, little is known …

The potential of human induced pluripotent stem cell differentiated cardiomyocytes (hiPSC-
CMs) is greatly limited by their functional immaturity. Strong relationships exist between …

Background β-catenin, acting as the core effector of canonical Wnt signaling pathway, plays
a pivotal role in controlling lineage commitment and the formation of definitive endoderm …

Human pluripotent stem cells (hPSCs) dynamically respond to their chemical and physical
microenvironment, dictating their behavior. However, conventional in vitro studies …

Background Human induced pluripotent stem cells (hiPSCs) provide an in vitro system to
identify the impact of cell behavior on the earliest stages of cell fate specification during …