Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …

Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and
represent an emerging therapeutic paradigm in cancer. However, their therapeutic potential …

The large family of deubiquitinating enzymes (DUBs) are involved in the regulation of a
plethora of processes carried out inside the cell by protein ubiquitination. Ubiquitination is a …

Down syndrome (DS), or trisomy 21, is one of the critical risk factors for early-onset
Alzheimer's disease (AD), implicating key roles for chromosome 21–encoded genes in the …

The mitochondrial-anchored deubiquitinating enzyme USP30 (ubiquitin specific peptidase
30) antagonizes PRKN/parkin-mediated mitophagy, making it a potential target for treating …

Ubiquitination and deubiquitination play a critical role in all aspects of cellular processes,
and the enzymes involved are tightly regulated by multiple factors including posttranslational …

Deubiquitinases (DUBs) are required for the reverse reaction of ubiquitination and act as
major regulators of ubiquitin signaling processes. Emerging evidence suggests that these …

Metazoan development from a one-cell zygote to a fully formed organism requires complex
cellular differentiation and communication pathways. To coordinate these processes …