Overview of hepatocellular carcinoma: from molecular aspects to future therapeutic options

S Panneerselvam, C Wilson, P Kumar… - Cell Adhesion & …, 2023 - Taylor & Francis
Hepatocellular carcinoma (HCC) is the seventh most highly prevalent malignant tumor
globally and the second most common cause of mortality. HCC develops with complex …

Viral hepatitis and hepatocellular carcinoma: State of the art

T Datfar, M Doulberis, A Papaefthymiou, IN Hines… - Pathogens, 2021 - mdpi.com
Viral hepatitis is one of the main causes leading to hepatocellular carcinoma (HCC). The
continued rise in incidence of HCC suggests additional factors following infection may be …

Viral biomarkers for hepatitis B virus-related hepatocellular carcinoma occurrence and recurrence

Y Liu, V Veeraraghavan, M Pinkerton, J Fu… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the fourth
leading cause of cancer-related death. The most common risk factor for developing HCC is …

Antiviral therapy reduces mortality in hepatocellular carcinoma patients with low-level hepatitis B viremia

X Wang, X Liu, P Wang, L Yu, F Yan… - Journal of …, 2021 - Taylor & Francis
Background and Aims Although antiviral treatment has been shown to reduce mortality in
hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients with high HBV-DNA …

[HTML][HTML] Predictive Risk Factors and Scoring Systems Associated with the Development of Hepatocellular Carcinoma in Chronic Hepatitis B

P Pastras, E Zazas, M Kalafateli, I Aggeletopoulou… - Cancers, 2024 - mdpi.com
Simple Summary Chronic hepatis B still remains a global epidemic and one of the leading
causes of hepatocellular carcinoma worldwide. We aimed to find out possible factors that …

Host cytokine genetic polymorphisms in a selected population of persons living with hepatitis B virus infection in the central region of Ghana

F Adu, E Aniakwaa-Bonsu, S Badu Nyarko… - BMC …, 2024 - Springer
Abstract Background Hepatitis B virus (HBV) infection is a public health concern in resource
limited settings like Ghana. Over the past decades, it is noted that the natural course of HBV …

[HTML][HTML] PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis

YM Choi, J Jang, DH Kim, Z Kim, E Kim, WH Choe… - JHEP Reports, 2024 - Elsevier
Abstract Background & Aims Deletion of 15 to 21 nucleotides covering the preS1 start codon
frequently occurs in chronic hepatitis B patients with HBV genotype C and has been …

Serum PreS1 and HBsAg ratio reflects liver fibrosis and predicts the development of hepatocellular carcinoma in chronic hepatitis B patients

Y Nishida, M Imamura, Y Teraoka, K Morio… - Journal of Viral …, 2021 - Wiley Online Library
While the preS1 region of the large hepatitis B surface protein plays an essential role in
hepatitis B virus (HBV) infection, the effect of preS1 on liver fibrosis and …

[HTML][HTML] Development and evaluation of a semi-nested PCR technique for amplification and determination of different surface gene variation patterns in patients with …

F Mokhtari, H Kaboosi, SR Mohebbi… - … and Hepatology From …, 2023 - ncbi.nlm.nih.gov
Aim: Development of an amplification method for further investigation of HBV S gene
variation patterns. Background: Pre-S/S variants in patients with chronic HBV infection may …

[HTML][HTML] Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy

H Lu, W Yi, F Sun, Z Zeng, L Zhang, M Li, Y Xie - Biosafety and Health, 2021 - Elsevier
Chronic hepatitis B virus (HBV) infection is a global public health problem, which can cause
chronic hepatitis, liver cirrhosis, hepatocellular carcinoma (HCC), and other diseases …