Recent advances in the diagnosis, risk stratification, and management of systemic light-chain amyloidosis

I Vaxman, M Gertz - Acta Haematologica, 2019 - karger.com
The term amyloidosis refers to a group of disorders in which protein fibrils accumulate in
certain organs, disrupt their tissue architecture, and impair the function of the effected organ …

Amyloidosis: What does pathology offer? The evolving field of tissue biopsy

M Riefolo, M Conti, S Longhi, B Fabbrizio… - Frontiers in …, 2022 - frontiersin.org
Since the mid-nineteenth century pathology has followed the convoluted story of
amyloidosis, recognized its morphology in tissues and made identification possible using …

[HTML][HTML] Congo red staining in digital pathology: the streamlined pipeline for amyloid detection through Congo red fluorescence digital analysis

G Cazzaniga, MM Bolognesi, MD Stefania… - Laboratory …, 2023 - Elsevier
Renal amyloidosis is a rare condition caused by the progressive accumulation of misfolded
proteins within glomeruli, vessels, and interstitium, causing functional decline and requiring …

Spatial resolution of renal amyloid deposits through MALDI-MSI: a combined digital and molecular approach to monoclonal gammopathies

G Bindi, A Smith, G Oliveira, A Eccher… - Journal of Clinical …, 2024 - jcp.bmj.com
Aims Identification and characterisation of monoclonal gammopathies of renal significance
(MGRS) is critical for therapeutic purposes. Amyloidosis represents one of the most common …

Renal amyloidosis: validation of a proposed histological scoring system in an independent cohort

JJ Hoelbeek, J Kers, EJ Steenbergen… - Clinical Kidney …, 2021 - academic.oup.com
Background In systemic amyloidosis, the kidney is frequently affected and renal involvement
has a major impact on survival. Renal involvement is clinically characterized by decreased …

Enhancing prognostic guidance in renal light-chain amyloidosis: a new staging system incorporating pathological characters

Y Xing, Y Qin, X Li, D Wang, J Zhao, W Zheng… - … Urology and Nephrology, 2024 - Springer
Background Advancements in treatment regimens have led to improved outcomes in renal
Immunoglobulin light-chain amyloidosis. Nevertheless, a subset of patients may still …

Whole tissue proteomic analyses of cardiac ATTR and AL unveil mechanisms of tissue damage

BC Netzel, MC Charlesworth, KL Johnson, AJ French… - Amyloid, 2025 - Taylor & Francis
Abstract Background Cardiac AL and ATTR are potentially fatal cardiomyopathies. Current
therapies do not address mechanisms of tissue dysfunction because these remain unknown …

Restless legs syndrome shows increased silent postmortem cerebral microvascular disease with gliosis

AS Walters, P Paueksakon, CH Adler… - Journal of the …, 2021 - Am Heart Assoc
Background Patients with restless legs syndrome (RLS) have increased silent microvascular
disease by magnetic resonance imaging. However, there has been no previous autopsy …

Light-chain (AL) amyloidosis for nephrologists—treatment standard

S Anand, M O'Neill-Dee… - Nephrology Dialysis …, 2025 - academic.oup.com
Amyloidosis is a group of complex diseases caused by the misfolding and aggregation of
proteins into amyloid fibrils. Light-chain (AL) amyloidosis is one of the most prevalent forms …

[HTML][HTML] 4 例重链或轻重链肾淀粉样变性患者的临床病理特点

赵冬慧, 李丹阳, 张帆, 屈磊, 张颖… - Journal of Peking …, 2020 - ncbi.nlm.nih.gov
4例重链或轻重链肾淀粉样变性患者的临床病理特点- PMC Back to Top Skip to main content
NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main …