There continues to be debate about the influence of personality disorder on the outcome of
depressive disorders and is relative interactions with treatment. To determine whether …

Objective: Treatment resistance is a common clinical phenomenon in depression. However,
current unitary models of staging fail to represent its complexity. We aimed to devise a model …

The issue of the severity of psychiatric disorders has great clinical importance. For example,
severity influences decisions about level of care, and affects decisions to seek government …

Background: Medication adherence is critical to the effectiveness of psychopharmacologic
therapy. Psychiatric disorders present special adherence considerations, notably an altered …

This paper is based on a report commissioned by the Subcommittee on Mental Health
Interface With General Medicine of the Presidents New Freedom Commission on Mental …

Background: Information on the naturalistic outcome of major depressive disorder (MDD) is
important in developing rational clinical practices. The aim of this study was to determine the …

Approximately 14% of older Americans are now taking an antidepressant. 1–3 However, this
broad use has not been associated with a notable decrease in the burden of geriatric …

Importance Nonadherence to antidepressant medication is common and leads to poor
outcomes. Early nonadherence is especially problematic. Objective To test the effectiveness …

BackgroundSystematic studies on the outcome of treatment-resistant depression are scarce.
AimsTo describe the longer-term outcome and predictors of outcome in treatment-resistant …

BackgroundDepressive disorders are known to often be chronic and recurrent both in the
general population and in psychiatric settings. However, despite its importance for public …