The kidney maintains electrolyte, water, and acid-base balance, eliminates foreign and
waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 …

Hypertension is available at http://hyper. ahajournals. org DOI: 10.1161/HYP.
0000000000000047 e8 Hypertension September 2016 distributed trait. Therefore, defining …

Massively parallel DNA-sequencing systems provide sequence of huge numbers of different
DNA strands at once. These technologies are revolutionizing our understanding in medical …

For many years, linkage analysis was the primary tool used for the genetic mapping of
Mendelian and complex traits with familial aggregation. Linkage analysis was largely …

Until recently, significant advances in our understanding of the mechanisms of blood
pressure regulation arose from studies of monogenic forms of hypertension and …

Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

The distal convoluted tubule is the nephron segment that lies immediately downstream of
the macula densa. Although short in length, the distal convoluted tubule plays a critical role …

The WNK-SPAK/OSR1 kinase complex is composed of the kinases WNK (with no lysine)
and SPAK (SPS1-related proline/alanine-rich kinase) or the SPAK homolog OSR1 (oxidative …

Glioblastoma is one of the most challenging forms of cancer to treat. Here we describe a
computational platform that integrates the analysis of copy number variations and somatic …

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets
(the SPAK/OSR1 kinases and the cation-Cl− cotransporters [CCCs]), comprise a signaling …