This paper aims to provide an important update on the recent preclinical and clinical trials
using cell therapy strategies and engineered heart tissues for the treatment of postinfarction …

Cardiovascular disease is one of the leading causes of mortality worldwide. Cardiac tissue
engineering strategies focusing on biomaterial scaffolds incorporating cells and growth …

Tu et al Strategies to Promote Cardiac Maturation 513 in previous iPSC-CM models.
Together, these results indicate an advanced level of maturity, both structurally and …

Direct cellular reprogramming provides a powerful platform to study cell plasticity and
dissect mechanisms underlying cell fate determination. Here, we report a single-cell …

Directly reprogramming fibroblasts into cardiomyocytes improves cardiac function in the
infarcted heart. However, the low efficacy of this approach hinders clinical applications …

Proximity proteomics has greatly advanced the analysis of native protein complexes and
subcellular structures in culture, but has not been amenable to study development and …

RNA therapeutics hold significant promise in the treatment of cardiovascular diseases.
RNAs are biologically diverse and functionally specific and can be used for gain-or loss-of …

Cardiovascular disease (CVD) is the leading cause of death in the United States, and diet
plays an instrumental role in CVD development. Plant-based diets have been strongly tied to …

In contrast to neonates and lower organisms, the adult mammalian heart lacks any capacity
to regenerate following injury. The vast majority of our understanding of cardiac …

Ischemic heart disease is the leading cause of morbidity, mortality, and healthcare
expenditure worldwide due to an inability of the heart to regenerate following injury. Thus …