As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum
Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the …

Mitochondria are key structures providing most of the energy needed to maintain
homeostasis. They are the main source of adenosine triphosphate (ATP), participate in …

Background Oxidative stress and damage are associated with a number of ageing
phenotypes, including age‐related loss of muscle mass and reduced contractile function …

Neuronal oxidative stress has been implicated in aging and neurodegenerative disease.
Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord …

Sarcopenia, the age-related decline in muscle mass and function, derives from multiple
etiological mechanisms. Accumulative research suggests that reactive oxygen species …

Age‐related muscle atrophy and weakness, or sarcopenia, are significant contributors to
compromised health and quality of life in the elderly. While the mechanisms driving this …

Muscle weakness associated with sarcopenia is a major contributor to reduced health span
and quality of life in the elderly. However, the underlying mechanisms of muscle weakness …

Background Cancer is associated with muscle atrophy (cancer cachexia) that is linked to up
to 40% of cancer‐related deaths. Oxidative stress is a critical player in the induction and …

Significance: Cancer is frequently associated with the early appearance of cachexia, a
multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a …

Age‐associated loss of muscle mass and function (sarcopenia) has a profound effect on the
quality of life in the elderly. Our previous studies show that CuZnSOD deletion in mice …