Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) constitute the core components of the …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

The ability to quantify cellular heterogeneity is a major advantage of single-cell
technologies. However, statistical methods often treat cellular heterogeneity as a nuisance …

The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune
responses. Additionally, aberrant NF-κB signaling has been identified in many types of …

A general mechanism for how intracellular signaling pathways in human pluripotent cells
are coordinated and how they maintain self-renewal remain to be elucidated. In this report …

Pluripotency and self-renewal are the hallmarks of embryonic stem cells. This state is
maintained by a network of transcription factors and is influenced by specific signalling …

Using a high-throughput chemical screen, we identified two small molecules that enhance
the survival of human embryonic stem cells (hESCs). By characterizing their mechanisms of …

During embryogenesis and tissue maintenance and repair in an adult organism, a myriad of
stem cells are regulated by their surrounding extracellular matrix (ECM) enriched with …

Cancer cells have the ability to divide indefinitely and spread to different parts of the body
during metastasis. Embryonic stem cells can self-renew and, through differentiation to …

ELABELA (ELA) is a peptide hormone required for heart development that signals via the
Apelin Receptor (APLNR, APJ). ELA is also abundantly secreted by human embryonic stem …