Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

Presence of benzimidazole nucleus in numerous categories of therapeutic agents such as
antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antioxidants, proton …

INTRODUCTION The four-component Ugi reaction (Ugi-4CR) assembles peptide-like α-
acylaminoamides through one-pot reaction of a carbonyl compound, an amine, an acid, and …

Abstract The Drug Design Data Resource (D3R) ran Grand Challenge 2 (GC2) from
September 2016 through February 2017. This challenge was based on a dataset of …

We present the performance of HADDOCK, our information-driven docking software, in the
second edition of the D3R Grand Challenge. In this blind experiment, participants were …

Disubstituted benzimidazoles play an important role in several areas and particularly as
drug discovery targets. Herein, several methods to assemble these structures are reviewed …

FXR agonists have demonstrated very promising clinical results in the treatment of liver
disorders such as primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and …

As a cellular bile acid sensor, farnesoid X receptor (FXR) participates in regulation of bile
acid, lipid and glucose homeostasis, and liver protection. Clinical results have validated FXR …

Iridium(III)-Catalyzed Synthesis of Benzimidazoles via C–H Activation and Amidation of
Aniline Derivatives | Organic Letters ACS ACS Publications C&EN CAS Find my institution …

This study was undertaken to evaluate the antidiabetic, hypolipidemic, and hepatoprotective
effects of methanol and aqueous extracts of Ganoderma applanatum (MEGA, AEGA) in …