Cytomegalovirus therapy: role of letermovir in prophylaxis and treatment in transplant recipients

JL Saullo, RA Miller - Annual Review of Medicine, 2023 - annualreviews.org
Cytomegalovirus (CMV) is a common viral pathogen in the transplant population and is
associated with significant morbidity and mortality. CMV prevention is paramount; however …

Management of cytomegalovirus infection in allogeneic hematopoietic stem cell transplants

F Allaw, SF Haddad, J Zakhour, SS Kanj - International Journal of …, 2023 - Elsevier
Cytomegalovirus (CMV) is a common infection encountered in immunocompromised
patients. It is associated with high morbidity and mortality, particularly in patients undergoing …

[HTML][HTML] Letermovir discontinuation at day 100 after allogeneic stem cell transplant is associated with increased CMV-related mortality

LW Liu, A Yn, F Gao, M Olson, M Crain… - … and Cellular Therapy, 2022 - Elsevier
Letermovir is approved by the Food and Drug Administration for cytomegalovirus (CMV)
prophylaxis in CMV seropositive recipients of allogeneic stem cell transplantation (alloSCT) …

The promising efficacy of a risk-based letermovir use strategy in CMV-positive allogeneic hematopoietic cell recipients

M Sourisseau, E Faure, H Béhal, P Chauvet… - Blood …, 2023 - ashpublications.org
Letermovir is the first approved drug for cytomegalovirus (CMV) infection prophylaxis in adult
patients who are CMV positive undergoing allogeneic hematopoietic cell transplantation …

Extended-duration letermovir prophylaxis for cytomegalovirus infection after cord blood transplantation in adults

I Politikos, C Lau, SM Devlin, S Quach, A Lin… - Blood …, 2022 - ashpublications.org
Cord blood transplantation (CBT) can be complicated by a high incidence of clinically
significant cytomegalovirus infection (csCMVi). We have investigated the efficacy of …

Immunovirology of cytomegalovirus infection in allogeneic stem cell transplant recipients undergoing prophylaxis with letermovir: a narrative review

C Solano, E Giménez, E Albert… - Journal of Medical …, 2023 - Wiley Online Library
Abstract On November 7, 2017, the US Food and Drug Administration approved the use of
letermovir (LMV) for prophylaxis of cytomegalovirus (CMV) infection in adult CMV …

Patterns of CMV infection after letermovir withdrawal in recipients of posttransplant cyclophosphamide–based transplant

A Lin, S Brown, S Chinapen, YJ Lee, SK Seo… - Blood …, 2023 - ashpublications.org
Reactivation of latent cytomegalovirus (CMV) is increased in recipients of allogeneic
hematopoietic cell transplantation (allo-HCT) with seropositive CMV using posttransplant …

Features of cytomegalovirus DNAemia and virus‐specific T‐cell responses in allogeneic hematopoietic stem‐cell transplant recipients during prophylaxis with …

E Giménez, M Guerreiro, I Torres… - Transplant Infectious …, 2023 - Wiley Online Library
Background There is scarce information on the natural kinetics of cytomegalovirus (CMV)
DNAemia and dynamics of CMV‐specific T‐cell reconstitution in allogeneic hematopoietic …

Letermovir prophylaxis reduced cytomegalovirus reactivation and resistance post umbilical cord blood transplantation

B Yan, G Sun, Y Wu, W Wu, K Song… - British Journal of …, 2024 - Wiley Online Library
To explore the impact of letermovir (LET) prophylaxis on cytomegalovirus (CMV) reactivation
and resistance in both adult and paediatric umbilical cord blood transplantation (UCBT) …

Refractory cytomegalovirus infections in Chinese patients receiving allogeneic hematopoietic cell transplantation: a review of the literature

D Yang, Y Yao, Y Sun, E Jiang - Frontiers in Immunology, 2023 - frontiersin.org
In the absence of prophylactic therapy, cytomegalovirus (CMV) viremia is a common
complication following allogeneic hematopoietic cell transplantation (allo-HCT) and …