B cells are a major component of the tumour microenvironment, where they are
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …

There is abundant evidence that tumor-infiltrating CD8+ T cells contribute positively to
antitumor immunity; however, the role of tumor-infiltrating B cells (TIL-B) and plasma cells …

Evidence indicates that lung cancer development is a complex process that involves
interactions between tumor cells, stromal fibroblasts, and immune cells. Tumor-infiltrating …

The clinical relevance of the host immune system in breast cancer has long been
unexplored. Studies developed over the past decade have highlighted the biological …

Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes
(TILs) in breast cancer. Herein, the concepts for TILs assessment are laid out by pathologists …

Purpose Modulation of immunologic interactions in cancer tissue is a promising therapeutic
strategy. To investigate the immunogenicity of human epidermal growth factor receptor 2 …

Background High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by
extensive inter-and intratumour heterogeneity, resulting in persistent therapeutic resistance …

Abstract Purpose: CD8+ tumor-infiltrating lymphocytes (TIL) are key mediators of antitumor
immunity and are strongly associated with survival in virtually all solid tumors. However, the …

Conventional chemotherapeutics and targeted antineoplastic agents have been developed
based on the simplistic notion that cancer constitutes a cell-autonomous genetic or …

Multiple independent studies have shown that tumor-infiltrating lymphocytes (TIL) are
prognostic in breast cancer with potential relevance for response to immune-checkpoint …