malERA: an updated research agenda for malaria elimination and eradication
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …
overwhelming health, equity, and economic benefits. WHO and countries are setting …
Plasmodium sporozoite biology
F Frischknecht, K Matuschewski - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle
progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of …
progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of …
Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells
J Sassmannshausen, S Bennink, U Distler… - Molecular …, 2024 - Wiley Online Library
Transmission of malaria parasites to the mosquito is mediated by sexual precursor cells, the
gametocytes. Upon entering the mosquito midgut, the gametocytes egress from the …
gametocytes. Upon entering the mosquito midgut, the gametocytes egress from the …
Malaria vaccines
Introduction Eradication of malaria remains one of the main aims of medicine. Despite
progress in malaria treatment, mortality rate remains high, especially in the poorest parts of …
progress in malaria treatment, mortality rate remains high, especially in the poorest parts of …
Secretory organelle function in the Plasmodium sporozoite
SA Arredondo, A Schepis, L Reynolds, SHI Kappe - Trends in Parasitology, 2021 - cell.com
Plasmodium sporozoites exhibit a complex infection biology in the mosquito and
mammalian hosts. The sporozoite apical secretory organelles, the micronemes and …
mammalian hosts. The sporozoite apical secretory organelles, the micronemes and …
The Plasmodium circumsporozoite protein
The circumsporozoite protein (CSP) is one of the most studied proteins of the malaria
parasite. It is the target of the only licensed malaria vaccines and is essential for sporozoite …
parasite. It is the target of the only licensed malaria vaccines and is essential for sporozoite …
Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development
HN Bogale, TV Pascini, S Kanatani… - Proceedings of the …, 2021 - National Acad Sciences
Despite the critical role of Plasmodium sporozoites in malaria transmission, we still know
little about the mechanisms underlying their development in mosquitoes. Here, we use …
little about the mechanisms underlying their development in mosquitoes. Here, we use …
[HTML][HTML] Endogenous cysteine protease inhibitors in upmost pathogenic parasitic protozoa
The regulation of the activity of proteases by endogenous inhibitors is a common trend in
almost all forms of life. Here, we review the endogenous inhibitors of cysteine proteases of …
almost all forms of life. Here, we review the endogenous inhibitors of cysteine proteases of …
Identification and structure–activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease
In an effort to develop a potent anti-malarial agent against Plasmodium falciparum, a
structure-guided virtual screening using an in-house library comprising 652 compounds was …
structure-guided virtual screening using an in-house library comprising 652 compounds was …
Target-based virtual screening of natural compounds identifies a potent antimalarial with selective falcipain-2 inhibitory activity
A Uddin, S Gupta, T Mohammad, D Shahi… - Frontiers in …, 2022 - frontiersin.org
We employed a comprehensive approach of target-based virtual high-throughput screening
to find potential hits from the ZINC database of natural compounds against cysteine …
to find potential hits from the ZINC database of natural compounds against cysteine …