Recommendations for the management of hemophagocytic lymphohistiocytosis in adults
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: recommendations from the North American Consortium for Histiocytosis (NACHO)
MB Jordan, CE Allen, J Greenberg… - Pediatric blood & …, 2019 - Wiley Online Library
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …
Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study
Background A subset of patients with COVID-19 develops a hyperinflammatory syndrome
that has similarities with other hyperinflammatory disorders. However, clinical criteria …
that has similarities with other hyperinflammatory disorders. However, clinical criteria …
Benefit of anakinra in treating pediatric secondary hemophagocytic lymphohistiocytosis
EM Eloseily, P Weiser, CB Crayne… - Arthritis & …, 2020 - Wiley Online Library
Objective To assess the benefit of the recombinant human interleukin‐1 receptor antagonist
anakinra in treating pediatric patients with secondary hemophagocytic lymphohistiocytosis …
anakinra in treating pediatric patients with secondary hemophagocytic lymphohistiocytosis …
Hemophagocytic lymphohistiocytosis: an update on pathogenesis, diagnosis, and therapy
G Griffin, S Shenoi, GC Hughes - Best Practice & Research Clinical …, 2020 - Elsevier
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …
Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy
KM Mahadeo, SJ Khazal, H Abdel-Azim… - Nature Reviews …, 2019 - nature.com
In 2017, an autologous chimeric antigen receptor (CAR) T cell therapy indicated for children
and young adults with relapsed and/or refractory CD19+ acute lymphoblastic leukaemia …
and young adults with relapsed and/or refractory CD19+ acute lymphoblastic leukaemia …
Macrophage activation syndrome and secondary hemophagocytic lymphohistiocytosis in childhood inflammatory disorders: diagnosis and management
LA Henderson, RQ Cron - Pediatric Drugs, 2020 - Springer
Macrophage activation syndrome (MAS), a form of secondary hemophagocytic
lymphohistiocytosis, is a frequently fatal complication of a variety of pediatric inflammatory …
lymphohistiocytosis, is a frequently fatal complication of a variety of pediatric inflammatory …
Consensus-based guidelines for the recognition, diagnosis, and management of hemophagocytic lymphohistiocytosis in critically ill children and adults
OBJECTIVE: Hemophagocytic lymphohistiocytosis is a hyperinflammatory syndrome that
often requires critical care support and remains difficult to diagnose. These guidelines are …
often requires critical care support and remains difficult to diagnose. These guidelines are …
COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?
MJ Ombrello, GS Schulert - Translational Research, 2021 - Elsevier
Although interest in “cytokine storms” has surged over the past decade, it was massively
amplified in 2020 when it was suggested that a subset of patients with COVID-19 developed …
amplified in 2020 when it was suggested that a subset of patients with COVID-19 developed …
Anakinra treatment in macrophage activation syndrome: a single center experience and systemic review of literature
Our aim was to report our experiences of pediatric macrophage activation syndrome (MAS)
patients treated with anakinra and to review previous studies reporting anakinra treatment in …
patients treated with anakinra and to review previous studies reporting anakinra treatment in …