Alcoholism is a debilitating disorder for the individual and very costly for society. A major
goal of alcohol research is to understand the neural underpinnings associated with the …

Outbred mouse stocks, often used in genetics, toxicology and pharmacology research, have
been generated in rather haphazard ways. Understanding the characteristics of these stocks …

Abstract microRNAs (miRNAs) regulate expression by promoting degradation or repressing
translation of target transcripts. miRNA target sites have been catalogued in databases …

Because of intrinsic differences between humans and mice, no single mouse model can
represent all features of a complex human trait such as alcoholism. It is therefore necessary …

Background Alcohol use disorder is characterized by compulsive alcohol intake, or drinking
despite negative consequences. Previous studies have shown that female rodents have a …

Recently, we described a simple procedure, Drinking in the Dark (DID), in which C57BL/6J
mice self‐administer ethanol to a blood ethanol concentration (BEC) above 1 mg/ml. The …

Much evidence from studies in humans and animals supports the hypothesis that alcohol
addiction is a complex disease with both hereditary and environmental influences …

Binge drinking is prevalent and has serious biomedical consequences. In children,
adolescents, and young adults, it is a prominent risk factor for later development of alcohol …

Background: The role of the δ‐opioid receptor in ethanol drinking has remained unclear
despite the use of traditional pharmacological and correlational approaches. The results of …

Background: The γ‐aminobutyric acid type A receptors (GABARs) are involved in mediating
some of the behavioral effects of beverage alcohol (ethanol). However, the unique …