Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because
of the growing threat of multi-and pan-drug-resistant bacterial pathogens globally. However …

Endosymbiotic bacteria have evolved intricate delivery systems that enable these organisms
to interface with host biology. One example, the extracellular contractile injection systems …

Microbiome research is now demonstrating a growing number of bacterial strains and genes
that affect our health. Although CRISPR-derived tools have shown great success in editing …

Bacteriophages, the viruses infecting bacteria, hold great potential for the treatment of
multidrug-resistant bacterial infections and other applications due to their unparalleled …

In recent years, bacteriophage research has been boosted by a rising interest in using
phage therapy to treat antibiotic-resistant bacterial infections. In addition, there is a desire to …

Although bacteriophages have been overshadowed as therapeutic agents by antibiotics for
decades, the emergence of multidrug-resistant bacteria and a better understanding of the …

Highlights•Synthetic biology enables efficient phage genome engineering.•Phages with
tunable host range and antimicrobial payload delivery enhance efficacy.•Phage design …

The rapid detection and species-level differentiation of bacterial pathogens facilitates
antibiotic stewardship and improves disease management. Here, we develop a rapid …

The evolution of antibiotic-resistant bacteria threatens to become the leading cause of
worldwide mortality. This crisis has renewed interest in the practice of phage therapy. Yet …