Schistosomes are parasitic worms that are a prime example of a complex multicellular
pathogen that flourishes in the human host despite the development of a pronounced …

Since the early 1950s, the dominant paradigm in the human genetics of infectious diseases
postulates that rare monogenic immunodeficiencies confer vulnerability to multiple infectious …

The host–parasite schistosome relationship relies heavily on the interplay between the
strategies imposed by the schistosome worm and the defense mechanisms the host uses to …

Schistosomiasis is a serious global helminthic disease, in which the main immunopathology
consists of a granulomatous and fibrosing reaction against tissue‐trapped parasite eggs …

Millions of humans are exposed to schistosome infections, which cause severe kidney and
liver disease and 280,000 deaths annually. Th2-mediated immunity is critical to human …

Schistosomiasis is a major tropical disease caused by trematode helminths in which the host
mounts a pathogenic immune response against tissue-trapped parasite eggs. The …

Coevolution between host and parasite is, in principle, a powerful determinant of the biology
and genetics of infection and disease. However, coevolution is difficult to demonstrate …

Immunity against schistosomes includes anti‐infection immunity, which is mainly active
against invading larvae in the skin, and anti‐disease immunity, which controls abnormal …

Hepatosplenic schistosomiasis involving organomegaly, portal fibrosis and portal
hypertension has been observed in autopsy studies. Here, we have tested the hypothesis …

We have identified a significant focus and unusual clustering of human cases of cystic
echinococcosis (CE) and alveolar echinococcosis (AE) in the village of Nanwan, Xiji County …