Rationale Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and
intensive therapy unit mortality but has not been assessed as a risk factor for acute …

Vitamin D regulates cell proliferation, inhibits cytokines release at sites of inflammation and
reduces inflammatory responses. In this study, the aim was to investigate whether …

Interactions between platelets, leukocytes and the vessel wall provide alternative
pathological routes of thrombo-inflammatory leukocyte recruitment. We found that when …

There is no therapeutic intervention proven to prevent acute respiratory distress syndrome
(ARDS). Novel mechanistic insights into the pathophysiology of ARDS are therefore …

Background Acute Respiratory Distress Syndrome (ARDS) is a devastating pulmonary
inflammatory disorder, commonly precipitated by sepsis. Glucocorticoids are …

Objectives: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and
ICU mortality but causality of these associations has not been demonstrated. To determine …

Increased endothelial permeability is central to the pathogenesis of sepsis and leads to
organ dysfunction and death but the endogenous mechanisms that drive increased …

Pneumonia-induced lung injury and acute respiratory distress syndrome can develop
because of an inappropriate inflammatory response to acute infections, leading to a …

Loss of control in the trafficking of immune cells to the inflamed lung tissue contributes to the
pathogenesis of life-threatening acute lung injury (ALI) and its more severe form, acute …

Streptococcus pneumoniae (Sp), a leading cause of community-acquired pneumonia, can
spread from the lung into the bloodstream to cause septicemia and meningitis, with a …