Improving protection to prevent bacterial infections: preliminary applications of reverse vaccinology against the main cystic fibrosis pathogens

M Cocorullo, LR Chiarelli, G Stelitano - Vaccines, 2023 - mdpi.com
Reverse vaccinology is a powerful tool that was recently used to develop vaccines starting
from a pathogen genome. Some bacterial infections have the necessity to be prevented then …

Emerging and alternative strategies for the treatment of nontuberculous mycobacterial infections

A Sreekumar, A Kumar, R Biswas… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction Nontuberculous mycobacteria (NTM) infections have emerged as a significant
clinical challenge due to their intrinsic multidrug resistance and the limited efficacy of …

[HTML][HTML] Phage Therapy: An Alternative Approach to Combating Multidrug-Resistant Bacterial Infections in Cystic Fibrosis

M Cocorullo, G Stelitano, LR Chiarelli - International Journal of Molecular …, 2024 - mdpi.com
Patients with cystic fibrosis (CF) are prone to developing life-threatening lung infections with
a variety of pathogens that are difficult to eradicate, such as Burkholderia cepacia complex …

Tackling Microbial Resistance and Emerging Pathogens with Next-Generation Antibiotics

KJ Chong, H Feng, V Letchumanan… - Progress In Microbes …, 2024 - hh-publisher.com
In the 19 th century, the discovery of penicillin revolutionized medicine, saving millions from
infectious diseases. People believed that they had won the war against infections. However …

Distinct Effects of Moxifloxacin and Bedaquiline on Growing and 'Non-Culturable' Mycobacterium abscessus

AL Mulyukin, D Recchia, NA Kostrikina, MV Artyukhina… - Microorganisms, 2023 - mdpi.com
Mycobacterium abscessus has recently emerged as the cause of an increasing number of
human infections worldwide. Unfortunately, it is highly resistant to existing drugs, and new …

Moles of Molecules against Mycobacterium abscessus: A Review of Current Research

M Cocorullo, C Bettoni, S Foiadelli, G Stelitano - Future Pharmacology, 2023 - mdpi.com
Mycobacterium abscessus is an emerging opportunistic pathogen that infects mainly the
respiratory tract of individuals with pre-existing clinical pictures. In recent years, the …

Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus

M Casanova, M Maresca, I Poncin, V Point… - Journal of Biomedical …, 2024 - Springer
Background Mycobacterium abscessus, a fast-growing non-tuberculous mycobacterium, is
an emerging opportunistic pathogen responsible for chronic bronchopulmonary infections in …

[HTML][HTML] Structural basis for specific inhibition of salicylate synthase from Mycobacterium abscessus

M Mori, M Cocorullo, A Tresoldi, G Cazzaniga… - European Journal of …, 2024 - Elsevier
Blocking iron uptake and metabolism has been emerging as a promising therapeutic
strategy for the development of novel antimicrobial compounds. Like all mycobacteria, M …

Fate of in vitro cultured Mycobacterium abscessus populations when exposed to moxifloxacin

EG Salina, BA Martini, VV Sorokin… - Frontiers in …, 2024 - frontiersin.org
Given the current need for predictive persisting model for Mycobacterium abscessus, we
adopted a classical assay to study drug-tolerant bacterial persisters, focusing on the …

[HTML][HTML] Mycobacteriophages and Their Applications

A Bonacorsi, C Ferretti, M Di Luca, L Rindi - Antibiotics, 2024 - pmc.ncbi.nlm.nih.gov
Mycobacterial infections caused by tuberculous and non-tuberculous strains pose significant
treatment challenges, especially among immunocompromised patients. Conventional …