Glycosylation is a co-and post-translational modification that is critical for the regulation of
the biophysical properties and biological activities of diverse proteins. Biosynthetic pathways …

A promising direction for the replacement of expanded bone defects is the development of
bioimplants based on synthetic biocompatible materials impregnated with growth factors that …

As one of the most complex post-translational modification, glycosylation is widely involved
in cell adhesion, cell proliferation and immune response. Nevertheless glycoproteins with an …

The sperm-specific phospholipase C zeta (PLCζ) protein is widely considered as the
predominant physiological stimulus for initiating the Ca2+ release responsible for oocyte …

Three variants of human recombinant erythropoietin (rhEPO) with additional N-terminal
protein domains were obtained by synthesis in an Escherichia coli heterologous expression …

Background Protein solubility characteristics are important determinants of success for
recombinant proteins in relation to expression, purification, storage and administration …

A wide range of glycoproteins can be recombinantly expressed in aglycosylated forms in
bacterial and cell-free production systems. To investigate the effect of glycosylation of these …

Fusokines are chimeric proteins generated by the physical coupling of cytokines in a single
polypeptide, resulting in proteins with highly pleiotropic activity and the potential to treat …

The aim of this work was to compare biological activities of three variants of bacterially
expressed human recombinant erythropoietin (EPO) with additional protein domains: 6His-s …

Cancer is one of the most significant health problems worldwide and thus the development
of novel therapeutic agents with fewer side effects is required. The present study …