[HTML][HTML] The role of mitochondrial dynamics in human cancers
Y Ma, L Wang, R Jia - American journal of cancer research, 2020 - ncbi.nlm.nih.gov
Mitochondria are crucial cellular organelles. Under extracellular stimulations, mitochondria
undergo constant fusion and fission dynamics to meet different cellular demands …
undergo constant fusion and fission dynamics to meet different cellular demands …
[HTML][HTML] The role of Aurora-A in human cancers and future therapeutics
X Lin, X Xiang, L Hao, T Wang, Y Lai… - American journal of …, 2020 - ncbi.nlm.nih.gov
Aurora-A is a mitotic serine/threonine-protein kinase and an oncogene. In normal cells,
Aurora-A appears from G2 phase and localizes at the centrosome, where it participates in …
Aurora-A appears from G2 phase and localizes at the centrosome, where it participates in …
Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity
Reactive oxygen species (ROS) are physiological mediators of cellular signaling and play
potentially damaging roles in human diseases. In this study, we found that the catalytic …
potentially damaging roles in human diseases. In this study, we found that the catalytic …
The multifaceted regulation of mitochondrial dynamics during mitosis
E Pangou, I Sumara - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Mitosis ensures genome integrity by mediating precise segregation of the duplicated genetic
material. Segregation of subcellular organelles during mitosis also needs to be tightly …
material. Segregation of subcellular organelles during mitosis also needs to be tightly …
Aurora kinase A/AURKA functionally interacts with the mitochondrial ATP synthase to regulate energy metabolism and cell death
RK Sharma, A Chafik, G Bertolin - Cell Death Discovery, 2023 - nature.com
Cancer cells often hijack metabolic pathways to obtain the energy required to sustain their
proliferation. Understanding the molecular mechanisms underlying cancer cell metabolism …
proliferation. Understanding the molecular mechanisms underlying cancer cell metabolism …
eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
The translation elongation factor eEF1A promotes protein synthesis. Its methylation by
METTL13 increases its activity, supporting tumor growth. However, in some cancers, a high …
METTL13 increases its activity, supporting tumor growth. However, in some cancers, a high …
Insights into the non-mitotic functions of Aurora kinase A: more than just cell division
G Bertolin, M Tramier - Cellular and Molecular Life Sciences, 2020 - Springer
AURKA is a serine/threonine kinase overexpressed in several cancers. Originally identified
as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy …
as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy …
Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer
The Aurora-A kinase regulates cell division, by controlling centrosome biology and spindle
assembly. Cancer cells often display elevated levels of the kinase, due to amplification of the …
assembly. Cancer cells often display elevated levels of the kinase, due to amplification of the …
[HTML][HTML] Aurora A kinase activation: Different means to different ends
Aurora A is a serine/threonine kinase essential for mitotic entry and spindle assembly.
Recent molecular studies have revealed the existence of multiple, distinct mechanisms of …
Recent molecular studies have revealed the existence of multiple, distinct mechanisms of …
PINK1 controls RTN3L-mediated ER autophagy by regulating peripheral tubule junctions
Here, we report that the RTN3L–SEC24C endoplasmic reticulum autophagy (ER-phagy)
receptor complex, the CUL3KLHL12 E3 ligase that ubiquitinates RTN3L, and the FIP200 …
receptor complex, the CUL3KLHL12 E3 ligase that ubiquitinates RTN3L, and the FIP200 …