Continuous manufacturing–the Green Chemistry promise?
Continuous manufacturing and Green Chemistry, are two promising approaches to
synthesis with underutilized potential that are gaining traction by the wider pharmaceutical …
synthesis with underutilized potential that are gaining traction by the wider pharmaceutical …
Continuous crystallization processes in pharmaceutical manufacturing: A review
J Orehek, D Teslic, B Likozar - Organic Process Research & …, 2020 - ACS Publications
This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …
Progress to date in the design and operation of continuous crystallization processes for pharmaceutical applications
Continuous crystallization has gained interest in the pharmaceutical sector as part of the
drive toward the transition from exclusive batch manufacturing to integrated continuous …
drive toward the transition from exclusive batch manufacturing to integrated continuous …
The Rocky Road From Fed-Batch to Continuous Processing With E. coli
Escherichia coli still serves as a beloved workhorse for the production of many
biopharmaceuticals as it fulfills essential criteria, such as having fast doubling times …
biopharmaceuticals as it fulfills essential criteria, such as having fast doubling times …
Progress and opportunities for utilizing seeding techniques in crystallization processes
Seeding is a significant but challenging task for optimizing crystallization process operation,
product quality, and process efficiency. With the development of modern crystallization …
product quality, and process efficiency. With the development of modern crystallization …
Recent progress in continuous crystallization of pharmaceutical products: precise preparation and control
Crystallization, as a solid–liquid separation process, is employed to purify and isolate a
great diversity of crystalline pharmaceutical products. In recent years, continuous …
great diversity of crystalline pharmaceutical products. In recent years, continuous …
[HTML][HTML] An audit of pharmaceutical continuous manufacturing regulatory submissions and outcomes in the US
AC Fisher, W Liu, A Schick, M Ramanadham… - International Journal of …, 2022 - Elsevier
Continuous manufacturing (CM) sends materials directly and continuously to the next step of
a process, eliminating hold times and reducing processing times. The potential benefits of …
a process, eliminating hold times and reducing processing times. The potential benefits of …
Digital design of an integrated purification system for continuous pharmaceutical manufacturing
In this work dynamic models of the continuous crystallization, filtration, deliquoring, washing,
and drying steps are introduced, which are developed in the open-source pharmaceutical …
and drying steps are introduced, which are developed in the open-source pharmaceutical …
API continuous cooling and antisolvent crystallization for kinetic impurity rejection in cGMP manufacturing
MD Johnson, CL Burcham, SA May… - … Process Research & …, 2021 - ACS Publications
Crystallization of 204 kg of final active pharmaceutical ingredient was accomplished
continuously using a cascade of mixed suspension mixed product removal crystallizers in …
continuously using a cascade of mixed suspension mixed product removal crystallizers in …
Evaluation of focused beam reflectance measurement (FBRM) for monitoring and predicting the crystal size of carbamazepine in crystallization processes
Pharmaceutical crystallization has an impact on the properties of active pharmaceutical
ingredients as it determines the purity, crystal size distribution and polymorphs, among other …
ingredients as it determines the purity, crystal size distribution and polymorphs, among other …