Retinoblastoma (RB) is the most common intraocular malignancy in childhood.
Approximately 40% of retinoblastomas are hereditary and due to germline mutations in the …

Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to
preserve life, with ocular survival, visual preservation and quality of life as secondary aims …

The pediatric ocular cancer retinoblastoma is the only central nervous system (CNS) tumor
readily observed without specialized equipment: it can be seen by, and in, the naked eye …

Purpose To compare metastasis-related mortality, local treatment failure and globe salvage
after retinoblastoma (RB) in countries with different national income levels. Design …

Tumors of the pineal region comprise several different entities with distinct clinical and
histopathological features. Whereas some entities predominantly affect adults …

Purpose To evaluate the ability of the 8th edition of the American Joint Committee on Cancer
(AJCC) Cancer Staging Manual to estimate metastatic and mortality rates for children with …

An understanding of the role of inherited cancer predisposition syndromes in pediatric tumor
diagnoses continues to develop as more information is learned through the application of …

Imaging is fundamental to diagnosis and management of pediatric patients with cancer and
cancer predisposition syndromes (CPSs). Whole-body MRI has emerged as a versatile tool …

Background: Uveal melanoma (UM) is the most common primary intraocular malignancy in
adults arising from uveal tissue melanocytes. Considering limited population based studies …

The use of standardized imaging protocols is paramount in order to facilitate comparable,
reproducible images and, consequently, to optimize patient care. Standardized MR …