Amide bonds occur in over half of target compounds in medicinal chemistry patents, making
amide bond formation the most commonly performed reaction in the pharmaceutical …

Hydrolases are well-known for hydrolyzing esters, amides, carbamates, peptides, or acid
anhydrides in the presence of water. However, some of them are also capable of catalyzing …

Promiscuous hydrolases/acyltransferases have attracted attention for their ability to
efficiently catalyze selective transacylation reactions in water to produce esters, thioesters …

The genus Mycobacterium comprises not only the deadliest of bacterial pathogens,
Mycobacterium tuberculosis, but several other pathogenic species, including M. avium and …

This article reviews the structures and biological activities of several classes of uridine-
containing nucleoside antibiotics (tunicamycins, mureidomycins/pacidamycins …

The amide moiety belongs to the most common motives in pharmaceutical chemistry,
present in many prescribed small-molecule pharmaceuticals. Methods for its manufacture …

Covering: up to September 2020 Hundreds of nucleoside-based natural products have been
isolated from various microorganisms, several of which have been utilized in agriculture as …

Modified nucleosides produced by Streptomyces and related actinomycetes are widely used
in agriculture and medicine as antibacterial, antifungal, anticancer and antiviral agents …

A growing number of hydrolase enzymes show promiscuous acyltransferase activity, even
under aqueous conditions. Here we report, for the first time, the ability of Pyrobaculum …

Antibiotic resistance poses an increasing threat to global health, and it is urgent to reverse
the present trend by accelerating development of new natural product derived drugs …