Collagen structure and stability

MD Shoulders, RT Raines - Annual review of biochemistry, 2009 - annualreviews.org
Collagen is the most abundant protein in animals. This fibrous, structural protein comprises
a right-handed bundle of three parallel, left-handed polyproline II-type helices. Much …

Cis− trans isomerization of organic molecules and biomolecules: implications and applications

C Dugave, L Demange - Chemical reviews, 2003 - ACS Publications
Organic molecules as well as metal complexes may exist as several geometric isomers1
which display distinct physical properties and chemical reactivities. A molecule containing …

Collagen interactions: Drug design and delivery

B An, YS Lin, B Brodsky - Advanced drug delivery reviews, 2016 - Elsevier
Collagen is a major component in a wide range of drug delivery systems and biomaterial
applications. Its basic physical and structural properties, together with its low …

Crystal structure of the collagen triple helix model [(Pro‐Pro‐Gly)10]3

R Berisio, L Vitagliano, L Mazzarella… - Protein Science, 2002 - Wiley Online Library
The first report of the full‐length structure of the collagen‐like polypeptide [(Pro‐Pro‐Gly) 10]
3 is given. This structure was obtained from crystals grown in a microgravity environment …

n→π* Interactions of Amides and Thioamides: Implications for Protein Stability

RW Newberry, B VanVeller, IA Guzei… - Journal of the American …, 2013 - ACS Publications
Carbonyl–carbonyl interactions between adjacent backbone amides have been implicated
in the conformational stability of proteins. By combining experimental and computational …

Stereoelectronic and steric effects in side chains preorganize a protein main chain

MD Shoulders, KA Satyshur… - Proceedings of the …, 2010 - National Acad Sciences
Preorganization is shown to endow a protein with extraordinary conformational stability. This
preorganization is achieved by installing side-chain substituents that impose …

Stereoelectronic and steric effects in the collagen triple helix: toward a code for strand association

JA Hodges, RT Raines - Journal of the American Chemical …, 2005 - ACS Publications
Collagen is the most abundant protein in animals. The protein consists of a helix of three
strands, each with sequence X− Y− Gly. Natural collagen is most stable when X is (2 S) …

Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary …

S Saxena, T Madan, A Shah, K Muralidhar… - Journal of Allergy and …, 2003 - Elsevier
Background: Studies from our group have shown a protective role of pulmonary surfactant
protein A (SP-A) against lung allergy and infections caused by Aspergillus fumigatus …

Tuning the cis/trans Conformer Ratio of Xaa–Pro Amide Bonds by Intramolecular Hydrogen Bonds: The Effect on PPII Helix Stability

M Kuemin, YA Nagel, S Schweizer… - Angewandte …, 2010 - Wiley Online Library
Isomerizations between cis and trans conformers in Xaa–Pro amide bonds (Xaa= any amino
acid, Pro= proline) are crucial in many natural processes such as protein folding and signal …

4-Fluoroprolines: Conformational analysis and effects on the stability and folding of peptides and proteins

RW Newberry, RT Raines - Peptidomimetics I, 2017 - Springer
Proline is unique among proteinogenic amino acids because a pyrrolidine ring links its
amino group to its side chain. This heterocycle constrains the conformations of the main …