Nerve terminals are specific sites of action of a very large number of toxins produced by
many different organisms. The mechanism of action of three groups of presynaptic …

The human brain has approximately 10 12 neurons, three orders of magnitude more than
there are basepairs in the human genome. Each neuron is connected to other neurons by …

Teneurins are ancient metazoan cell adhesion receptors that control brain development and
neuronal wiring in higher animals. The extracellular C terminus binds the adhesion GPCR …

Latrophilin 1 (LPH1), a neuronal receptor of α-latrotoxin, is implicated in neurotransmitter
release and control of presynaptic Ca2+. As an “adhesion G-protein-coupled receptor,” …

It was long ago that group analysis of differential equations became a powerful tool for
studying nonlinear equations and boundary value problems. This analysis was especially …

G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control
cellular states in response to soluble extracellular cues. However, the modality of stimuli …

Secretion of the peptide hormone insulin from pancreatic β cells constitutes an important
step in the regulation of body homeostasis. Insulin is stored in large dense core vesicles and …

Abstract α-Latrotoxin is a potent stimulator of neurosecretion. Its action requires extracellular
binding to high affinity presynaptic receptors. Neurexin Iα was previously described as a …

α-Latrotoxin (LTX) stimulates massive exocytosis of synaptic vesicles and may help to
elucidate the mechanism of regulation of neurosecretion. We have recently isolated …

The G-protein-coupled receptor CIRL1/latrophilin-1 (CL1) and the type-1 membrane
proteins neurexins represent distinct neuronal cell adhesion molecules that exhibit no …