Currently, antimicrobial resistance (AMR) is a serious health problem in the world, mainly
because of the rapid spread of multidrug-resistant (MDR) bacteria. These include bacteria …

Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there
is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate …

β-lactams are the most prescribed class of antibiotics due to their potent, broad-spectrum
antimicrobial activities. However, alarming rates of antimicrobial resistance now threaten the …

The most common mechanism of the resistance to β-lactam antibiotics is the
expIdentification of cisplatin and palladiuression of β-lactamases, which can hydrolyze the β …

Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes
have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One …

Inhibition of bacterial virulence is believed to be a new treatment option for bacterial
infections. In the present study, we tested dipicolylamine (DPA), tripicolylamine (TPA), tris …

The superbug infection mediated by metallo-β-lactamases (MβLs) has grown into
anemergent health threat, and development of MβL inhibitors is an ideal strategy to combat …

The syntheses of metallo-β-lactamase inhibitors comprising chelating moieties, with varying
zinc affinities, and peptides partly inspired from bacterial peptide sequences, have been …

The “superbug” infection caused by metallo-β-lactamases (MβLs) has grown into
anemergent health threat, and development of effective MβL inhibitors to restore existing …

In this work, the use of DPA-triazole (DPA= dipicolylamine) molecules as ligands for metal
catalyzed organic reactions has been investigated. A small library of ligands has been …