Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …

The contribution of nerves to the pathogenesis of malignancies has emerged as an
important component of the tumour microenvironment. Recent studies have shown that …

Pancreatic ductal adenocarcinoma (PDAC) tumors have a nutrient-poor, desmoplastic, and
highly innervated tumor microenvironment. Although neurons can release stimulatory factors …

Pancreatic ductal adenocarcinoma (PDA) has become one of the leading causes of cancer-
related deaths across the world. A lack of durable responses to standard-of-care …

Pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CCA) are both deadly
cancers and they share many biological features besides their close anatomical location …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant disease with a
unique tumor microenvironment surrounded by an interlaced network of cancer and …

Perineural invasion (PNI) is the process of neoplastic invasion of peripheral nerves and is
considered to be the fifth mode of cancer metastasis. PNI has been detected in head and …

Perineural invasion (PNI) is a pathologic feature of pancreatic cancer and is associated with
poor outcomes, metastasis, and recurrence in pancreatic cancer patients. However, the …

Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer,
frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent …

Perineural invasion (PNI) is defined as the presence of neoplastic cells along nerves and/or
within the different layers of nervous fibers: epineural, perineural and endoneural spaces. In …