The carbamate group is a key structural motif in many approved drugs and prodrugs. There
is an increasing use of carbamates in medicinal chemistry and many derivatives are …

HIV-1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS,
transforming this deadly ailment into a more manageable chronic infection. Over the years …

The purpose of this study was to characterize the antiviral activity, cytotoxicity, and
mechanism of action of TMC114, a novel human immunodeficiency virus type 1 (HIV-1) …

Either amprenavir (1) or its C (2) diastereomer can be synthesized in a simple way by the
use of a nitroaldol reaction carried out in the presence of one or the other of the two …

The V82F/I84V double mutation is considered as the key residue mutation of the HIV-1
protease drug resistance because it can significantly lower the binding affinity of protease …

The discovery of human immunodeficiency virus (HIV) protease inhibitors (PIs) and their
utilization in highly active antiretroviral therapy (HAART) have been a major turning point in …

The screening of known HIV-1 protease inhibitors against a panel of multi-drug-resistant
viruses revealed the potent activity of TMC126 on drug-resistant mutants. In comparison to …

The compound UIC-94017 (TMC-114) is a second-generation HIV protease inhibitor with
improved pharmacokinetics that is chemically related to the clinical inhibitor amprenavir. UIC …

Drug resistance is prevalent across many diseases, rendering therapies ineffective with
severe financial and health consequences. Rather than accepting resistance after the fact …

The evolution of drug resistance is one of the most fundamental problems in medicine. In
HIV/AIDS, the rapid emergence of drug‐resistant HIV‐1 variants is a major obstacle to …