Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

The strategy of clinically targeting cancerous cells at their most vulnerable state during
mitosis has instigated numerous studies into the mitotic cell death (MCD) pathway. As the …

Although they have been advocated with an understandable enthusiasm, mitosis-specific
agents such as inhibitors of mitotic kinases and kinesin spindle protein have not been …

Nature has yielded numerous compounds that bind to tubulin/microtubules and disrupt
microtubule function. Even with the advent of targeted therapies for cancer, natural products …

Introduction: Leukoplakia is the most frequent pre-blastomatous alteration in the oral cavity.
Its potential for malignant transformation is unpredictable. The aim of the present study was …

Background Androgen ablation is the standard treatment for advanced prostate cancer but
the short‐term cellular effects are largely unknown. Methods Sextant prostate biopsies were …

Purpose To elucidate the pathomechanism of Fuchs' dystrophy and pseudophakic bullous
keratopathy (PBK) by examining cell apoptosis in different corneal layers. Methods The …

Although no optimal treatment is currently available for malignant brain tumors, as the
molecular mechanisms underlying brain tumor development have been delineated, new …

OBJECTIVES To assess the early histological effects of pharmacological androgen
deprivation (AD), which have been assessed only over longer periods, as surgical castration …