Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

Spreading depression (SD) and the related hypoxic SD-like depolarization (HSD) are
characterized by rapid and nearly complete depolarization of a sizable population of brain …

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Accurate and continuous in vivo measurements of brain interstitial substance concentrations
provide a major technical challenge. Among the many innovations that have appeared over …

Background A brief period of global brain ischemia causes cell death in hippocampal CA1
pyramidal neurons days after reperfusion in rodents and humans. Other neurons are much …

Glutamate neurotransmitter action on postsynaptic receptors is terminated by its clearance
from the synaptic cleft by transporter proteins located in neurons and glial cells. Failure of …

We evaluated whether regional differences in the magnitude of glutamate, γ‐aminobutyric
acid (GABA), and glycine release could explain why some regions are vulnerable to …

Delayed or secondary neuronal damage following traumatic injury to the central nervous
system (CNS) may result from pathologic changes in the brain's endogenous neurochemical …

Historically, glutamate uptake in the CNS was mainly attributed to glial cells for three
reasons: 1) none of the glutamate transporters were found to be located in presynaptic …