Inflammation has been recognized as a major pathophysiological contributor to the entire
spectrum of human heart failure (HF), including HF with reduced ejection fraction, HF with …

Sufficient epidemiological investigations demonstrate that there is a close correlation
between obesity and vascular dysfunction. Nevertheless, specific mechanisms underlying …

Nonresolving inflammation underlies a range of chronic inflammatory diseases, and
therapeutic acceleration of resolution of inflammation may improve outcomes. Neural …

Chronic inflammation is a hallmark of atherosclerosis and results from an imbalance
between proinflammatory and proresolving signaling. The human GPR32 receptor, together …

(1) Background: Obesity is closely connected to the pathophysiology of cardiovascular
diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that …

Sex differences in cardiovascular disease (CVD), including aortic stenosis, atherosclerosis
and cardiovascular calcification, are well documented. High levels of testosterone, the …

Introduction: Most ischemic strokes develop as a result of atherosclerosis, in which
inflammation plays a key role. The synthesis cascade of proinflammatory mediators …

Pulmonary arterial hypertension (PAH) is a devastating disease characterized by severe
pulmonary vascular wall remodeling and perivascular inflammation. Resolvin E1 (RvE1), a …

Repairing the human brain remains a challenge, despite the advances in the knowledge of
inflammatory response to injuries and the discovery of adult neurogenesis. After brain injury …

The immune system is weakened by advancing age, often referred to as
immunosenescence, increasing the vulnerability to, and frequently the severity of, infectious …