Drug resistance in Leishmania: does it really matter?

MA Domagalska, MP Barrett, JC Dujardin - Trends in Parasitology, 2023 - cell.com
Abstract Treatment failure (TF) jeopardizes the management of parasitic diseases, including
leishmaniasis. From the parasite's point of view, drug resistance (DR) is generally …

Impact of Genetic Diversity and Genome Plasticity of Leishmania spp. in Treatment and the Search for Novel Chemotherapeutic Targets

AMM Santi, SMF Murta - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Leishmaniasis is one of the major public health concerns in Latin America, Africa, Asia, and
Europe. The absence of vaccines for human use and the lack of effective vector control …

Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae

ATS Albanaz, M Carrington, AO Frolov, AI Ganyukova… - BMC genomics, 2023 - Springer
Background Protists of the family Trypanosomatidae (phylum Euglenozoa) have gained
notoriety as parasites affecting humans, domestic animals, and agricultural plants. However …

[HTML][HTML] Surveillance of leishmaniasis cases from 15 European centres, 2014 to 2019: a retrospective analysis

G Van der Auwera, L Davidsson, P Buffet… - …, 2022 - eurosurveillance.org
Background Surveillance of human leishmaniasis in Europe is mostly limited to country-
specific information from autochthonous infections in the southern part. As at the end of …

Stress conditions promote Leishmania hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq

I Louradour, TR Ferreira, E Duge, N Karunaweera… - Elife, 2022 - elifesciences.org
Leishmania are protozoan parasites transmitted by the bite of sand fly vectors producing a
wide spectrum of diseases in their mammalian hosts. These diverse clinical outcomes are …

Ecological divergence and hybridization of Neotropical Leishmania parasites

F Van den Broeck, NJ Savill… - Proceedings of the …, 2020 - National Acad Sciences
The tropical Andes are an important natural laboratory to understand speciation in many
taxa. Here we examined the evolutionary history of parasites of the Leishmania braziliensis …

Colonization and genetic diversification processes of Leishmania infantum in the Americas

P Schwabl, MC Boité, G Bussotti, A Jacobs… - Communications …, 2021 - nature.com
Leishmania infantum causes visceral leishmaniasis, a deadly vector-borne disease
introduced to the Americas during the colonial era. This non-native trypanosomatid parasite …

First report of cutaneous leishmaniasis caused by Leishmania donovani in Ethiopia

GA Amare, GG Mekonnen, M Kassa, A Addisu… - Parasites & …, 2023 - Springer
Background Leishmaniasis is a common neglected tropical disease in Ethiopia. Visceral
leishmaniasis (VL) caused by Leishmania donovani presents in the lowlands, while …

High throughput single-cell genome sequencing gives insights into the generation and evolution of mosaic aneuploidy in Leishmania donovani

GH Negreira, P Monsieurs, H Imamura… - Nucleic acids …, 2022 - academic.oup.com
Leishmania, a unicellular eukaryotic parasite, is a unique model for aneuploidy and cellular
heterogeneity, along with their potential role in adaptation to environmental stresses. Somy …

Repurposing the antibacterial agents peptide 19-4LF and peptide 19-2.5 for treatment of cutaneous leishmaniasis

R El-Dirany, C Fernández-Rubio, J Peña-Guerrero… - Pharmaceutics, 2022 - mdpi.com
The lack of safe and cost-effective treatments against leishmaniasis highlights the urgent
need to develop improved leishmanicidal agents. Antimicrobial peptides (AMPs) are an …