This review describes the development of the Molecular Microscope Diagnostic System
(MMDx) for heart transplant endomyocardial biopsies (EMBs). MMDx-Heart uses …

Production of de novo donor-specific antibodies (dnDSA) is a major risk factor for acute and
chronic antibody-mediated rejection and graft loss after all solid organ transplantation. In this …

We studied the clinical, histologic, and molecular features distinguishing DSA-negative from
DSA-positive molecularly defined antibody-mediated rejection (mABMR). We analyzed …

Background Elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the plasma of
renal allograft recipients indicates organ injury and an increased probability of active …

Background The Molecular Microscope (MMDx) system classifies heart transplant
endomyocardial biopsies as No-rejection (NR), Early-injury, T cell-mediated (TCMR) …

Donor-specific antibodies (DSA) are integral to the development of antibody-mediated
rejection (AMR). Chronic AMR is associated with high mortality and an increased risk for …

Human leukocyte antigen (HLA) compatibility is very important for successful transplantation
of solid organs. In this paper, we focused on the humoral arm of immunity in the clinical …

The development of sensitive methods for alloantibody detection has been a significant
advance in clinical transplantation. However, the complexity of the data from solid phase …

Background The impact of Luminex-detected HLA antibodies on outcomes after lung
transplantation is unclear. Herein we have undertaken a retrospective study of pre …

Long-term kidney transplant outcomes remain suboptimal, delineating an unmet medical
need. Although current immunosuppressive therapy in kidney transplant recipients is …