Sex differences in autism spectrum disorder: diagnostic, neurobiological, and behavioral features

A Napolitano, S Schiavi, P La Rosa… - Frontiers in …, 2022 - frontiersin.org
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with a
worldwide prevalence of about 1%, characterized by impairments in social interaction …

Synaptopathology involved in autism spectrum disorder

S Guang, N Pang, X Deng, L Yang, F He… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …

RNA-binding proteins balance brain function in health and disease

R Schieweck, J Ninkovic… - Physiological reviews, 2021 - journals.physiology.org
Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

K Sawicka, CR Hale, CY Park, JJ Fak, JE Gresack… - Elife, 2019 - elifesciences.org
Loss of the RNA binding protein FMRP causes Fragile X Syndrome (FXS), the most common
cause of inherited intellectual disability, yet it is unknown how FMRP function varies across …

Of men and mice: modeling the fragile X syndrome

R Dahlhaus - Frontiers in molecular neuroscience, 2018 - frontiersin.org
The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …

[HTML][HTML] Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies

A Banerjee, MF Ifrim, AN Valdez, N Raj, GJ Bassell - Brain research, 2018 - Elsevier
Research in the past decades has unfolded the multifaceted role of Fragile X mental
retardation protein (FMRP) and how its absence contributes to the pathophysiology of …

Molecular mechanisms of synaptic dysregulation in fragile X syndrome and autism spectrum disorders

M Telias - Frontiers in molecular neuroscience, 2019 - frontiersin.org
Fragile X syndrome (FXS) is the most common form of monogenic hereditary cognitive
impairment. FXS patient exhibit a high comorbidity rate with autism spectrum disorders …

Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes

C Szpirer - Journal of biomedical science, 2020 - Springer
The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …

Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin

Y Liu, L Shan, T Liu, J Li, Y Chen, C Sun, C Yang… - Neuron, 2023 - cell.com
Maternal affiliation by infants is the first social behavior of mammalian animals. We report
here that elimination of the Tph2 gene essential for serotonin synthesis in the brain reduced …

Modeling Fragile X Syndrome in Drosophila

M Drozd, B Bardoni, M Capovilla - Frontiers in Molecular …, 2018 - frontiersin.org
Intellectual disability (ID) and autism are hallmarks of Fragile X Syndrome (FXS), a
hereditary neurodevelopmental disorder. The gene responsible for FXS is Fragile X Mental …