Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities

X Jiang, K Wu, R Bai, P Zhang, Y Zhang - European Journal of Medicinal …, 2022 - Elsevier
Quinoxalinones are a class of heterocyclic compounds which attract extensive attention
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …

An insight into medicinal chemistry of anticancer quinoxalines

T Kaushal, G Srivastava, A Sharma, AS Negi - Bioorganic & Medicinal …, 2019 - Elsevier
Quinoxalines are benzopyrazines containing benzene and pyrazine rings fused together. In
the recent past, quinoxalines have attracted Medicinal Chemists considerably for their …

Enantioselective chemodivergent three-component radical tandem reactions through asymmetric photoredox catalysis

C Ma, J Shen, C Qu, T Shao, S Cao, Y Yin… - Journal of the …, 2023 - ACS Publications
Chemodivergent synthesis has been achieved in asymmetric photocatalysis. Under a dual
catalyst system consisting of a chiral phosphoric acid and DPZ as a photosensitizer, different …

Quinoxalinone as a privileged platform in drug development

L Shi, W Hu, J Wu, H Zhou, H Zhou… - Mini Reviews in …, 2018 - ingentaconnect.com
Among the family of nitrogen-containing heterocycles, quinoxalinone (or quinoxalin-2-one)
core, characterized by pyrazin-2 (1H)-one fused to benzene ring at two adjacent carbon …

Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitors

EA Fayed, YA Ammar, MA Saleh, AH Bayoumi… - Journal of Molecular …, 2021 - Elsevier
A new series of quinoxaline derivatives synthesized and pharmacologically evaluated
against (HepG-2, HCT-116, and MCF-7) cell lines. Seven compounds were found to …

Electrochemical cascade sequences for remote C7–H bond thiocyanation of quinoxalin-2 (1 H)-ones with ammonium thiocyanate

R Maity, A Bankura, I Das - Green Chemistry, 2023 - pubs.rsc.org
The syntheses of C3-substituted quinoxalin-2 (1H)-one derivatives have been extensively
studied for decades, while the methods for direct functionalization at the embedded aromatic …

Recent synthetic developments and applications of the ullmann reaction. A review

H Lin, D Sun - Organic preparations and procedures international, 2013 - Taylor & Francis
The last century represents an exciting era for the chemical evolution of transition-metal
catalyzed reactions, 1–3 and among these, the chemistry of palladium, 4–6 ruthenium, 7–10 …

Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor

LJ Martin, AL Marzinzik, SV Ley, IR Baxendale - Organic Letters, 2011 - ACS Publications
A flow method for the synthesis of aliphatic and aromatic diazoketones from acyl chloride
precursors has been developed and used to prepare quinoxalines in a multistep sequence …

Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

OO Ajani - European journal of medicinal chemistry, 2014 - Elsevier
Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide
biological properties and diverse therapeutic applications in medicinal research. They are …

Benzodiazines: recent synthetic advances

T Mathew, AÁ Papp, F Paknia, S Fustero… - Chemical Society …, 2017 - pubs.rsc.org
Benzodiazines (diazonaphthalenes with both nitrogens in the same ring)–cinnolines (1, 2-
benzodiazine), quinazolines (1, 3-benzodiazine), phthalazines (2, 3-benzodiazine) and …