The role of lipids in providing energy and structural cellular components during vertebrate
development is poorly understood. To elucidate these roles further, we visualized lipid …

Improved understanding of lipoproteins, particles that transport lipids throughout the
circulation, is vital to developing new treatments for the dyslipidemias associated with …

Dyslipidemias are a major cause of morbidity and mortality in the world, particularly in
developed nations. Investigating lipid and lipoprotein metabolism in experimentally tractable …

Single-cell atlases pose daunting computational challenges pertaining to the integration of
spatial and temporal information and the visualization of trajectories across large atlases …

As one of the common birth defects worldwide, nonsyndromic microtia is a complex disease
that results from interactions between environmental and genetic factors. However, the …

Target biomarkers for H2 at both the protein and genome levels are still unclear. In this
study, quantitative proteomics acquired from a mouse model were first analyzed. At the …

Background Similar to humans, the zebrafish brain plays a central role in regulating sexual
reproduction, maturation and sexual behavior. However, systematic studies of the dimorphic …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of anticancer
treatment with microtubule-targeted agents (MTAs). The frequency of severe CIPN, which …

Abstract Syndecan-4 (Syn4), a single-pass transmembrane heparin sulphate proteoglycan
(HSPG), plays significant role in the formation of focal adhesions and interacts with many …

Microtubule targeting agents (MTAs) often lead to treatment limiting and life threatening side
effects, including chemotherapy-induced peripheral neuropathy (CIPN). The frequency of …