Reactive oxygen species (ROS) are produced by living organisms as a result of normal
cellular metabolism and environmental factors, such as air pollutants or cigarette smoke …

▪ Abstract This review describes the three mammalian glutathione transferase (GST)
families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated …

It has been established that oxidative stress, defined as the condition in which the sum of
free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the …

Reduced glutathione (GSH) is the most prevalent non-protein thiol in animal cells. Its de
novo and salvage synthesis serves to maintain a reduced cellular environment and the …

In addition to inducing new transcriptional activities that lead within a few hours to the
accumulation of heat shock proteins (Hsps), heat shock activates within minutes the major …

Abstract Glutathione-S-transferases (GSTs) are a family of Phase II detoxification enzymes
that catalyse the conjugation of glutathione (GSH) to a wide variety of endogenous and …

BACKGROUND: The cytosolic glutathione transferases (GSTs) comprise a super family of
proteins that can be categorized into multiple classes with a mixture of highly specific and …

Glutathione S-transferases (GSTs) are phase II detoxifying enzymes involved in the
maintenance of cell integrity, oxidative stress and protection against DNA damage by …

The expression of genes encoding antioxidative and Phase II detoxification enzymes is
induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of …

Glutathione transferases (GSTs) are enzymes that catalyze the conjugation of glutathione
(GSH) to a variety of electrophilic substances. Their best known role is as cell housekeepers …