Over 60 bromodomains belonging to proteins with very different functions have been
identified in humans. Several of them interact with acetylated lysine residues, leading to the …

Bromodomains are modulators of protein–protein interactions essential for epigenetic
mechanisms of transcriptional control. The recent disclosure of potent, selective, small …

The lysine acetyltransferases play crucial but complex roles in cancer development. GCN5
is a lysine acetyltransferase that generally regulates gene expression, but its role in cancer …

The recent disclosure of potent, selective small molecule inhibitors (I-BET762, I-BET151 and
JQ1) of the BET family of bromodomains demonstrate that epigenetic reader proteins may …

Alteration of the chromatin orchestra seems to play a critical role in cancer. In recent years,
in-depth studies of epigenetic machinery and its deregulation have led to the development …

Lysine acetylation is a critical post-translation modification that can impact a protein's
localization, stability, and function. Originally thought to only occur on histones, we now …

Gastric cancer is still the second leading cause of cancer-related death worldwide, even
though its incidence and mortality have declined over the recent few decades. Epigenetic …

Histone acetyltransferases (HATs) have a central role in the modification of chromatin as
well as in the pathogenesis of a broad set of diseases including cancers. Gcn5 is the first …

The incorporation of histone H3 with an acetylated lysine 56 (H3K56ac) into the nucleosome
is important for chromatin remodeling and serves as a marker of new nucleosomes during …

Human cancer is causally linked to genomic and epigenomic deregulations. Epigenetic
abnormalities occurring within signaling pathways regulating proliferation, migration, growth …