Astrocyte-neuron metabolic cooperation shapes brain activity

G Bonvento, JP Bolaños - Cell metabolism, 2021 - cell.com
The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

Astrocytes as key regulators of brain energy metabolism: new therapeutic perspectives

E Beard, S Lengacher, S Dias, PJ Magistretti… - Frontiers in …, 2022 - frontiersin.org
Astrocytes play key roles in the regulation of brain energy metabolism, which has a major
impact on brain functions, including memory, neuroprotection, resistance to oxidative stress …

[HTML][HTML] Global minimum estimates of children affected by COVID-19-associated orphanhood and deaths of caregivers: a modelling study

SD Hillis, HJT Unwin, Y Chen, L Cluver, L Sherr… - The Lancet, 2021 - thelancet.com
Background The COVID-19 pandemic priorities have focused on prevention, detection, and
response. Beyond morbidity and mortality, pandemics carry secondary impacts, such as …

Extant timetrees are consistent with a myriad of diversification histories

S Louca, MW Pennell - Nature, 2020 - nature.com
Time-calibrated phylogenies of extant species (referred to here as 'extant timetrees') are
widely used for estimating diversification dynamics. However, there has been considerable …

[HTML][HTML] Brain glucose metabolism: integration of energetics with function

GA Dienel - Physiological reviews, 2018 - journals.physiology.org
Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

Astrocyte function from information processing to cognition and cognitive impairment

M Santello, N Toni, A Volterra - Nature neuroscience, 2019 - nature.com
Astrocytes serve important roles that affect recruitment and function of neurons at the local
and network levels. Here we review the contributions of astrocyte signaling to synaptic …

Lactate in the brain: from metabolic end-product to signalling molecule

PJ Magistretti, I Allaman - Nature reviews neuroscience, 2018 - nature.com
Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

[HTML][HTML] Astrocytic activation generates de novo neuronal potentiation and memory enhancement

A Adamsky, A Kol, T Kreisel, A Doron… - Cell, 2018 - cell.com
Astrocytes respond to neuronal activity and were shown to be necessary for plasticity and
memory. To test whether astrocytic activity is also sufficient to generate synaptic potentiation …

Conceptual and empirical bridges between micro-and macroevolution

J Rolland, LF Henao-Diaz, M Doebeli… - Nature Ecology & …, 2023 - nature.com
Explaining broad molecular, phenotypic and species biodiversity patterns necessitates a
unifying framework spanning multiple evolutionary scales. Here we argue that although …

Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning

A Kol, A Adamsky, M Groysman, T Kreisel… - Nature …, 2020 - nature.com
Remote memories depend on coordinated activity in the hippocampus and frontal cortices,
but the timeline of these interactions is debated. Astrocytes sense and modify neuronal …