The lungs are exposed to reactive oxygen species oxygen (ROS) produced as a result of
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …

The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

Bone regeneration relies on the activation of skeletal stem cells (SSCs) that still remain
poorly characterized. Here, we show that periosteum contains SSCs with high bone …

Asthma is one of the most common chronic immunological diseases in humans, affecting
people from childhood to old age. Progress in treating asthma has been relatively slow and …

Asthma is a complex respiratory disorder characterized by marked heterogeneity in
individual patient disease triggers and response to therapy. Several asthma phenotypes …

Chronic rhinosinusitis (CRS) is a troublesome, chronic inflammatory disease that affects
over 10% of the adult population, causing decreased quality of life, lost productivity, and lost …

Background In phase 2 trials, lebrikizumab, an anti-interleukin-13 monoclonal antibody,
reduced exacerbation rates and improved FEV 1 in patients with uncontrolled asthma …

Asthma is a T lymphocyte–controlled disease of the airway wall caused by inflammation,
overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity …

Background Many patients with asthma have uncontrolled disease despite treatment with
inhaled glucocorticoids. One potential cause of the variability in response to treatment is …

Introduction In a subset of patients with asthma, standard-of-care treatment does not achieve
disease control, highlighting the need for novel therapeutic approaches. Lebrikizumab is a …