Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays vital
roles in modulating metabolism, immunity, and oncogenesis. ATF3 acts as a hub of the …

Abstract Inflammatory Bowel Diseases (IBD), namely Crohn's Disease and Ulcerative Colitis,
cause a significant disease burden in modern civilization. Ever since the introduction of anti …

The composition of the intestinal microbiota is associated with both the development of
tumors and the efficacy of anti-tumor immunity. Here, we examined the impact of microbiota …

The mammalian intestine harbors a remarkable number of microbes and their components
and metabolites, which are fundamental for the instigation and development of the host …

Neuronal signals have emerged as pivotal regulators of group 2 innate lymphoid cells
(ILC2s) that regulate tissue homeostasis and allergic inflammation. The molecular pathways …

T follicular helper (Tfh) cells with the phenotype of mainly expressing surface molecules
CXC motif chemokine receptor type 5 (CXCR5), inducible co-stimulator (ICOS), secreting …

Activating transcription factors, ATFs, are a group of bZIP transcription factors that act as
homodimers or heterodimers with a range of other bZIP factors. In general, ATFs respond to …

ATF3 has been reported to be dysregulated in various cancers and involved in various steps
of tumorigenesis. However, the mechanisms underlying the abnormal expression of ATF3 …

Mucosal surfaces in the gastrointestinal tract are continually exposed to native, commensal
antigens and susceptible to foreign, infectious antigens. Immunoglobulin A (IgA) provides …

In recent years it has become apparent that the epithelium is highly involved in inflammatory
bowel disease (IBD) pathophysiology. The majority of gene expression studies of IBD are …