Marine extremophiles: a source of hydrolases for biotechnological applications

GZL Dalmaso, D Ferreira, AB Vermelho - Marine drugs, 2015 - mdpi.com
The marine environment covers almost three quarters of the planet and is where evolution
took its first steps. Extremophile microorganisms are found in several extreme marine …

Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis

CM Clouthier, JN Pelletier - Chemical Society Reviews, 2012 - pubs.rsc.org
This critical review presents an introduction to biocatalysis for synthetic chemists. Advances
in biocatalysis of the past 5 years illustrate the breadth of applications for these powerful and …

Recent trends in biocatalysis engineering

A Illanes, A Cauerhff, L Wilson, GR Castro - Bioresource technology, 2012 - Elsevier
During the last 30years the scope of biocatalysis has been expanding due to the advances
in several technological fields. Diverse techniques as structural enzyme improvement (eg …

Multistep one-pot reactions combining biocatalysts and chemical catalysts for asymmetric synthesis

CA Denard, JF Hartwig, H Zhao - ACS catalysis, 2013 - ACS Publications
In a continuous effort to emulate the efficiency of biosynthetic pathways, considerable
progress has been made in developing one-pot chemoenzymatic processes that take full …

Light‐driven kinetic resolution of α‐functionalized carboxylic acids enabled by an engineered fatty acid photodecarboxylase

J Xu, Y Hu, J Fan, M Arkin, D Li, Y Peng… - Angewandte Chemie …, 2019 - Wiley Online Library
Chiral α‐functionalized carboxylic acids are valuable precursors for a variety of medicines
and natural products. Herein, we described an engineered fatty acid photodecarboxylase …

Biocatalyst development by directed evolution

M Wang, T Si, H Zhao - Bioresource technology, 2012 - Elsevier
Biocatalysis has emerged as a great addition to traditional chemical processes for
production of bulk chemicals and pharmaceuticals. To overcome the limitations of naturally …

Discovery and protein engineering of biocatalysts for organic synthesis

GA Behrens, A Hummel, SK Padhi… - Advanced Synthesis …, 2011 - Wiley Online Library
Modern tools for enzyme discovery and protein engineering substantially broadened the
number of enzymes applicable for biocatalysis and helped to alter their properties such as …

Enzymatic synthesis of enantiopure alcohols: current state and perspectives

BS Chen, FZR de Souza - RSC advances, 2019 - pubs.rsc.org
Enantiomerically pure alcohols, as key intermediates, play an essential role in the
pharmaceutical, agrochemical and chemical industries. Among the methods used for their …

The selective addition of water

V Resch, U Hanefeld - Catalysis Science & Technology, 2015 - pubs.rsc.org
Water is omnipresent and essential. Yet at the same time it is a rather unreactive molecule.
The direct addition of water to CC double bonds is therefore a challenge not answered …

A general protein purification and immobilization method on controlled porosity glass: Biocatalytic applications

KE Cassimjee, M Kadow, Y Wikmark… - Chemical …, 2014 - pubs.rsc.org
A general combined purification and immobilization method to facilitate biocatalytic process
development is presented. The support material, EziG™, is based on controlled porosity …