Designer drugs: mechanism of action and adverse effects

D Luethi, ME Liechti - Archives of toxicology, 2020 - Springer
Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

Serotonin syndrome: pathophysiology, clinical features, management, and potential future directions

WJ Scotton, LJ Hill, AC Williams… - International Journal of …, 2019 - journals.sagepub.com
Serotonin syndrome (SS)(also referred to as serotonin toxicity) is a potentially life-
threatening drug-induced toxidrome associated with increased serotonergic activity in both …

Reports of adverse events associated with use of novel psychoactive substances, 2013–2016: a review

BK Logan, ALA Mohr, M Friscia… - Journal of Analytical …, 2017 - academic.oup.com
Novel psychoactive substances (NPS) represent significant analytical and interpretive
challenges to forensic and clinical toxicologists. Timely access to case reports and reports of …

Pharmacology and Toxicology of N-Benzylphenethylamine (“NBOMe”) Hallucinogens

AL Halberstadt - … of New Psychoactive Substances (NPS) The Science …, 2017 - Springer
Serotonergic hallucinogens induce profound changes in perception and cognition. The
characteristic effects of hallucinogens are mediated by 5-HT 2A receptor activation. One …

The detection and prevention of unintentional consumption of DOx and 25x‐NBOMe at Portugal's boom festival

D Martins, MJ Barratt, CV Pires… - Human …, 2017 - Wiley Online Library
Objective This paper describes the misrepresentation of LSD at Portugal's Boom Festival
2014 and the prevention of unintentional consumption of DOx and 25x‐NBOMe among LSD …

A case study involving U-47700, diclazepam and flubromazepam—application of retrospective analysis of HRMS data

E Partridge, S Trobbiani, P Stockham… - Journal of Analytical …, 2018 - academic.oup.com
The number of new psychoactive substances (NPS) available is constantly increasing,
making it difficult for toxicology laboratories to keep screening methods up to date. Full scan …

Proposed confidence scale and ID score in the identification of known-unknown compounds using high resolution MS data

B Rochat - Journal of the American Society for Mass Spectrometry, 2017 - ACS Publications
High-resolution (HR) MS instruments recording HR-full scan allow analysts to go further
beyond pre-acquisition choices. Untargeted acquisition can reveal unexpected compounds …

Novel psychoactive substances—recent progress on neuropharmacological mechanisms of action for selected drugs

Z Hassan, OG Bosch, D Singh, S Narayanan… - Frontiers in …, 2017 - frontiersin.org
A feature of human culture is that we can learn to consume chemical compounds, derived
from natural plants or synthetic fabrication, for their psychoactive effects. These drugs …

Suspect screening using LC–QqTOF is a useful tool for detecting drugs in biological samples

JM Colby, KL Thoren, KL Lynch - Journal of analytical toxicology, 2018 - academic.oup.com
High-resolution mass spectrometers (HRMS), including quadrupole time of flight mass
analyzers (QqTOF), are becoming more prevalent as screening tools in clinical and forensic …

New psychoactive substances (NPS) prevalence over LSD in blotter seized in State of Santa Catarina, Brazil: a six-year retrospective study

B de Souza Boff, J Silveira Filho, K Nonemacher… - Forensic science …, 2020 - Elsevier
Designer drugs or new psychoactive substances (NPS) are a heterogeneous group of
substances obtained through the modification of chemical structure of some natural products …