Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Neurodegenerative disease (NDD), including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive loss of neurons which …

Rodent models have been extensively used to investigate the cause and mechanisms
behind Alzheimer's disease. Despite many years of intensive research using these models …

Objective To evaluate the bio-safety of graphene quantum dots (GQDs), we studied its
effects on the embryonic development of zebrafish. Methods In vivo, biodistribution and the …

Aluminium is a non-essential metal and potentially toxic to organisms whose environmental
concentration increases due to pollution. In our previous studies, the behavioral changes …

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder,
yet the genetic cause of up to 50% of cases remains unknown. Here, we show that mutations …

Amyloid is a term for the build-up of protein deposits or plaques in the body. Thus amyloid
are extracellular insoluble fibrous protein aggregates. One characteristic is that these fibrils …

Highlights•Abeta peptide biology rather than APP biology has been the main focus of AD
field in the past 20 years.•The amyloid cascade hypothesis failed to produce effective AD …

Tissue regeneration and functional restoration after injury are considered as stem-and
progenitor-cell-driven processes. In the central nervous system, stem cell-driven repair is …

Zebrafish behavior is influenced by the lateral line hair cells and muscles. Drug-induced
behavioral changes can serve as indicators in the evaluation of drug toxicity. The …